Magnetic Resonance Imaging (MRI) of Brain Iron in Neurodegenerative Disease

Mild Cognitive Impairment Clinical Trial

Official title:

High Field MRI of Brain Iron in Neurodegenerative Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00249080
• Other study ID #: AMC-IRB-1599
• Secondary ID: A-13214
• Status: Completed
• Phase: N/A
• First received: November 3, 2005
• Last updated: August 21, 2009
• Start date: June 2005
• Est. completion date: August 2007

Study information

• Verified date: August 2009
• Source: Albany Medical College
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis are recognized as a major health concern at the present time. There is information in magnetic resonance imaging (MRI) studies regarding the role of brain iron in normal brain aging that may be enhanced with the use of better scanning equipment and procedures, and by correlating this information with clinical data. This research study aims to develop and evaluate a number of techniques that can potentially improve the effectiveness of three tesla (3T) magnetic resonance imaging of neurodegenerative brain disorders.

Description:

Eligibility: A healthy person without memory complaints or someone with neurodegenerative disease. However, the person should not have metal in the body (ie, pacemaker, implants, shrapnel, etc.), should not be pregnant, and should not have claustrophobic anxieties.

Study Procedures: During a regular office visit, a neurologist will perform a routine physical and neurological examination, including your medical and family history, to determine your eligibility for this study. You will then be scheduled for a series of neuropsychological tests, which take between 1 to 1.5 hours, and an MRI scan, which takes approximately 1 hour to complete. This is a longitudinal study and you may be asked to repeat these procedures approximately every six months for the duration of this 2 year project.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 182
• Est. completion date: August 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years or older

• Healthy person without memory complaints OR person diagnosed with a neurodegenerative disease (ie, Alzheimer's disease, Parkinson's disease, multiple sclerosis)

Exclusion Criteria:

• MR contraindication such as metal in body (ie, pacemaker, implant, shrapnel, etc.)

• Pregnant

• Claustrophobic anxieties

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Cognition Disorders
• Mild Cognitive Impairment
• Neurodegenerative Diseases

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Albany Medical College	United States Department of Defense

References & Publications (3)

Schenck JF, Zimmerman EA. High-field magnetic resonance imaging of brain iron: birth of a biomarker? NMR Biomed. 2004 Nov;17(7):433-45. Review. — View Citation

Schenck JF. Magnetic resonance imaging of brain iron. J Neurol Sci. 2003 Mar 15;207(1-2):99-102. Review. — View Citation

Schenck JF. Safety of strong, static magnetic fields. J Magn Reson Imaging. 2000 Jul;12(1):2-19. Review. — View Citation