Migraines Clinical Trial
Official title:
Comparison of Ketorolac Nasal Spray to Sumatriptan Nasal Spray and Placebo for Acute Treatment of Migraine (The KSPN Migraine Study)
The investigators propose to test the efficacy of ketorolac nasal spray versus sumatriptan nasal spray versus placebo for acute abortive therapy of migraine head pain as well as for migraine associated symptoms including nausea and allodynia.
Participants are randomized to Ketorolac NS 31.5 mg, Sumatriptan NS 20 mg or placebo to
treat three moderate to severe migraine attacks and switched treatments with each attack so
that they received each treatment only once.
For each treated attack (moderate to severe migraine attack), participants utilized two
study treatments (A and B). Study treatment A administered as one spray in each nostril, and
study treatment B administered as one spray in one nostril.
Randomized to Ketorolac, A=Ketorolac, B=Placebo Randomized to Sumatriptan, A=Placebo,
B=Sumatriptan Randomized to Placebo, A=Placebo, B=Placebo
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