Mechanistic Studies of Psilocybin in Headache Disorders

Status Not yet recruiting

Clinical Trial Summary

In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect. This study will measure brain resting state functional connectivity (fMRI), central synaptic density (SV2A PET), peripheral markers of inflammation, circadian rhythm (actigraphy), and sleep (sleep EEG) in both migraine and healthy control participants before and one week after the administration of psilocybin or an active control agent.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06464367
Study type	Interventional
Source	Yale University
Contact	Heather Garrett, BS
Phone	203-937-5711
Email	heather.garrett@yale.edu
Status	Not yet recruiting
Phase	Early Phase 1
Start date	September 1, 2024
Completion date	December 31, 2026

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