Dose-Ranging Trial of Inhaled Cannabis for Acute Migraine Treatment

Status Suspended

Clinical Trial Summary

This pilot crossover study will evaluate 3 different potencies of inhaled cannabis (2.5%, 5%, and 10%) and inhaled placebo cannabis for the acute treatment of migraine.

Clinical Trial Description

In this double-blind, randomized, crossover trial, subjects will treat 4 separate migraine attacks with 4 different treatments. Inhaled cannabis will be administered using a portable system. Subjects will self-administer inhaled cannabis as early as possible in the course of a migraine, taking 4 puffs of 1) THC 2.5%, 2) THC 5%, 3) THC 10%, or 4) placebo. Patients will treat each of the 4 distinct migraine attacks with a different cannabis sample. Outcomes measured will include pain freedom, most bothersome symptom (MBS), and pain relief as well as presence or absence of photophobia, phonophobia, and nausea at 15 minutes, 30 minutes, 45 minutes, 1 hour, 1.5 hours, 2 hours, 4 hours, 24 hours, and 48 hours. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05427630
Study type	Interventional
Source	University of California, San Diego
Contact
Status	Suspended
Phase	Phase 2
Start date	February 15, 2023
Completion date	June 1, 2024

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