Migraine Clinical Trial
Official title:
The Effect of Sumatriptan and Placebo on CGRP Induced Headache
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with aCalcitonine Gene Related Peptide (CGRP). If the headache responds to sumatriptan, the model can be used to test new drug candidates.
There remains a great need for more effective anti-migraine drugs with fewer side effects.
Human experimental models are valuable in early phase development of new anti-migraine drugs
but useful models have not yet been developed. The investigators' group has shown that
Calcitonine Gene Related Peptide (CGRP) induce headache/migraine in both healthy volunteers
and in patients with migraine without aura (MO). To validate this model, the headache must
respond to specific migraine treatment with sumatriptan.
Hypothesis: CGRP induces a migraine-like headache in both healthy subjects and in MO-patients
and induced headache responds to a specific anti migraine drug; sumatriptan.
Aim: Developing a pragmatic and valid model for the testing of new anti-migraine drugs.
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