Migraine Clinical Trial
Official title:
Comparison of Treximet and Imitrex as They Affect the Levels of Inflammatory Markers When the Patient is Actively Having a Migraine Headache.
The primary objective is to determine whether inflammatory markers, such as C-Reactive
Protein (CRP), Calcitonin Gene-Related Peptide (CGRP), Vasoactive Intestinal Polypeptide
(VIP), or Substance P (SP) are reduced in patients having a migraine headache when treated
with Imitrex or Treximet.
The secondary objective is to determine the effects of Imitrex and Treximet on C-Reactive
Protein (CRP) in patients with active migraine headaches.
Migraine is a neurovascular process involving the brain and related structures.
Neuroinflammatory substances such as CRP, CGRP, VIP, SP, and prostaglandins are liberated
during the migraine. Elevation of these markers may be associated with other conditions
which contain an inflammatory component such as coronary artery disease. VIP is an
inflammation and pain transmission, and thus are markers of sensory nociceptive neurons.
During this study, the subjects will have the following inflammation markers analyzed:
C-Reactive Protein (CRP), Calcitonin Gene-Related Peptide (CGRP), Vasoactive Intestinal
Polypeptide (VIP), and Substance P (SP).
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Observational Model: Case-Crossover, Time Perspective: Prospective
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