Migraine Clinical Trial
Official title:
Prochlorperazine Verus Metoclopramide for the Treatment of Acute Migraine in the Emergency Department Setting
Migraine headaches are a common reason for patients to present to an emergency department. We are comparing two different medications to see which one is better for patients who present ot an emergency room with a migraine headache.
One-third of the five million headache patients who present to US Emergency Departments (ED)
annually have a migraine headache. The anti-emetic dopamine receptor antagonists have proven
efficacy for migraines, are at least as well-tolerated as triptans, and enjoy wide-spread use
in North American EDs. However, it is not yet clear which medication within this class and
which dosage is optimal. Therefore, we propose a randomized clinical trial to compare the
efficacy and tolerability of two standard medications for migraine.
Specific Aim: To compare the efficacy of metoclopramide versus prochlorperazine for the
emergency department treatment of migraine headaches. Both of these medications will be
combined with diphenhydramine to prevent extra-pyramidal side effects.
Patients will be enrolled as participants if they present to one of the participating EDs and
consent to participate. Medications will be administered as an intravenous drip over 15
minutes. Rescue medication will be administered, if needed, after one hour. A follow-up phone
call will be conducted 24 hours after the ED visit.
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