Migraine Clinical Trial
Official title:
The Effect of Glyceryl Trinitrate (GTN) and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI.
After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.
Experimental headache model open a unike opportunity to study the pathophysiological
mechanisms behind headache in general and migrane in particular. Previous studies have used
various techniques to study the cerebral haemodynamics as a basis for the headache
pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after
application of various pharmacological substances.
The most used experimental headache model is the glyceryl trinitrate model (GTN). Where
infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the
other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral
blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and
diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod
volume (CBV) via a 3-Tesla MRI.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Educational/Counseling/Training
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