Efficacy of rTMS in the Treatment of Patients With Migraine

Migraine Clinical Trial

Official title:

Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Migraine Using Somatosensory Evoked High-Frequency Oscillations as a Parameter: A 3-year Study.

Clinical Trial Details — Status: Unknown status

Administrative data

• NCT number: NCT00316979
• Other study ID #: rTMS_Migraine_VGHTPE
• Status: Unknown status
• Phase: N/A
• First received: April 20, 2006
• Last updated: June 6, 2010
• Start date: April 2006

Study information

• Verified date: June 2010
• Source: Taipei Veterans General Hospital, Taiwan
• Contact: Shuu-Jiun Wang, MD
• Phone: +886-2-28712121
• Email: sjwang[@]vghtpe.gov.tw
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Migraine is a condition thought to be related to cortical hyperexcitability. Repetitive transcranial magnetic stimulation (rTMS) can modulate the cortical excitability by means of long-term potentiation or long-term depression. This study will will test the safety and efficacy of rTMS in the treatment of patients with Migraine.

Recruitment information / eligibility

• Status: Unknown status
• Enrollment: 80
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Age of 18-65 years

• Diagnosed as migraine (with or without aura)

• More than 4 attacks per month for at least 3 months prior to study

• No preventive medication used

• Must be able to sign permit

Exclusion Criteria:

• History of seizure or family history of seizures

• Women in pregnancy or breast-feeding

• Patient with medication overuse

• Patient with other medical, psychologic, or surgical illness

• Patient under preventive medications

• Prior rTMS examination one month within

Related Conditions & MeSH terms

• Migraine
• Migraine Disorders

Intervention

Device:
• Repetitive Transcranial Magnetic Stimulation (rTMS)

Locations

Country	Name	City	State
Taiwan	Headache Center, Teipei Veterans General Hospital	Taipei

Sponsors (2)

Lead Sponsor	Collaborator
Taipei Veterans General Hospital, Taiwan	National Science Council, Taiwan

Country where clinical trial is conducted

Taiwan, 

References & Publications (2)

Brighina F, Piazza A, Vitello G, Aloisio A, Palermo A, Daniele O, Fierro B. rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci. 2004 Dec 15;227(1):67-71. — View Citation

Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain. 2003 May;126(Pt 5):1079-91. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reduction in days of migraine attack per month
Secondary	The reduction in dosage of acute abortive medication
Secondary	The reduction of headache index