| Eligibility |
Inclusion Criteria:
1. Male or female 18 to 65 years of age.
2. History of migraine with or without aura according to the International Classification
of Headache Disorders (ICHD)-3rd edition (beta version) for at least one-year with
first migraine prior to age 50.
3. Migraine-associated nausea with =half the migraine attacks.
4. 2 - 8 migraines per month in each of the previous 3 months.
5. The patient is able to complete study questionnaires, comply with the study
requirements and restrictions, and willing to provide written informed consent and
authorize HIPAA.
6. The female patient who is premenopausal or postmenopausal less than 1 year, or have
not had surgical sterilization (i.e., tubal ligation, partial or complete
hysterectomy) must have a negative urine pregnancy test, be non-lactating, and commit
to using 2 methods of adequate and reliable contraception throughout the study and for
28 days after taking the last dose of the study drug (e.g., barrier with additional
spermicidal, intra-uterine device, hormonal contraception). Male patients must be
surgically sterile or commit to the use of 2 different methods of birth control during
the study and for 28 days after the study.ice, hormonal contraception).
Exclusion Criteria:
1. The patient in the opinion of the investigator may have medication-overuse headaches
(as defined by ICHD - 3 beta criteria for medication-overuse headache) during the
preceding 3 months.
2. The patient in the opinion of the investigator has chronic migraine (as defined by
ICHD - 3 beta criteria for chronic migraine) during the preceding 3 months.
3. History of cluster headaches or neurologically complicated migraine (hemiplegic,
basilar, retinal, ophthalmoplegic).
4. Initiation or change in medications with possible migraine prophylactic effects during
3 months before inclusion into the trial (E.g., calcium channel blockers, tricyclic
antidepressants, beta-blockers, or Botox).
5. Use of opiates or barbiturates more than 3 days per month.
6. Any concurrent medical or psychiatric condition, this includes, but is not limited to
chronic unstable debilitating diseases, significant renal or hepatic impairment.
7. The patient has a history within the previous 3 years of abuse of any drug,
prescription, illicit, or alcohol.
8. The Female patient is pregnant or breast-feeding. The Male patient is not practicing 2
different methods of birth control with their partner during the study, and for 28
days after the investigational drug last dose or will not remain abstinent during the
study, and for 28 days after the last dose.
9. The patient has known-hypersensitivity reaction to any of the components of the
investigational drug.
10. Consumption of analgesic medication or muscle relaxants (including all
benzodiazepines) for other conditions on a regular basis.
11. The patient has used emergency care treatment more than 3 times in the previous 6
months.
12. The patient has participated in another study with an investigational drug within 30
days prior to randomization and/or plan to participate during the study.
13. The patient has a history of congenital heart disease, cardiac arrhythmias, or
cardiovascular disease, e.g., ischemic heart disease (e.g., stable angina pectoris,
unstable angina, vasospastic angina, myocardial infarction or silent myocardial
ischemia), cerebrovascular syndromes (e.g., strokes of any type or transient ischemic
attacks), peripheral vascular disease, ischemic bowel disease, or Raynaud syndrome.
14. Uncontrolled hypertension (sitting >160 mmHg systolic pressure or >95mmHg diastolic
pressure).
15. The patient, in the investigator's opinion, is likely to have unrecognized
cardiovascular or cerebrovascular disease.
16. History of epilepsy. Allergy to sulfonamides.
17. Consumption of monoamine oxidase inhibitor (MAOI) drug, tricyclic antidepressant,
selective serotonin reuptake inhibitor (SSRI) or Serotonin Noradrenaline Reuptake
Inhibitor (SNRI).
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