Migraine Disorders Clinical Trial
Official title:
A Ketogenic Diet Normalizes Interictal Cortical But Not Subcortical Responsivity in Migraineurs
A short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive
cortical response. Here, investigators aim to prove if the KD-related changes of cortical
excitability are primarily due to cerebral cortex activity or are modulated by the brainstem.
Through the stimulation of the right supraorbital division of the trigeminal nerve, there
will be concurrently interictally recorded the nociceptive blink reflex (nBR) and the
pain-related evoked potentials (PREP) in 18 migraineurs patients without aura before and
after 1-month on KD, while in metabolic ketosis. nBR and PREP reflect distinct brain
structures activation: the brainstem and the cerebral cortex respectively. It will be
estimated nBR R2 component area-under-the-curve as well as PREP amplitude habituation as the
slope of the linear regression between the 1st and the 2nd block of 5 averaged responses.
n/a
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