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Clinical Trial Summary

We will evaluate the effects of deep brain stimulation (DBS) of bilateral nucleus accumbens (NAc) added to background treatment for treatment refractory Methamphetamine Use Disorder (MUD). This is a small randomized cross-over study to demonstrate feasibility and safety, test treatment outcomes (use, craving), and identify novel biological targets (NAc local field potentials (LFP) and functional MRI).


Clinical Trial Description

In a randomized cross-over design of DBS of the nucleus accumbens (NAc) for treatment refractory methamphetamine use disorder (MUD, n=5), we will test safety, feasibility, effect on clinical outcomes (craving and use), and seek to identify biological targets (using cue craving during recording of local field potentials and MRI). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05558358
Study type Interventional
Source University of Colorado, Denver
Contact Joseph T Sakai, MD
Phone 303-724-7402
Email joseph.sakai@cuanschtz.edu
Status Recruiting
Phase Phase 1/Phase 2
Start date January 15, 2024
Completion date February 1, 2025

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