PraG With RANKL Inhibitor for the Treatment of Advanced Multiple Metastatic Solid Tumors

Metastatic Solid Tumor Clinical Trial

— PRaG 2X  

Official title:

PhaseⅠ-Ⅱ Clinical Study of Hypofractionated Radiotherapy Combined With PD-1 Inhibitor Sequential GM-CSF(PraG) With RANKL Inhibitor for the Treatment of Advanced Multiple Metastatic Solid Tumors

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05435768
• Other study ID #: JD-LK-2022-035-01
• Status: Not yet recruiting
• Start date: August 16, 2022
• Est. completion date: August 15, 2025

Study information

• Verified date: August 2022
• Source: Second Affiliated Hospital of Soochow University
• Contact: Yuehong Kong, Dr
• Phone: 13375183257
• Email: kkyuehong[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The PraG treatment model has synergistic effects with RANKL inhibitor therapy, and the combination of the two treatments provides a survival benefit for patients with multiple bone metastatic solid tumors who have failed first-line systemic therapy. Phase I clinical trial is planned to determine the safety of PraG treatment mode combined with RANKL inhibitor desomumab and the optimal treatment sequence and mode. Further phase II clinical trial was conducted to confirm the efficacy of PraG treatment combined with desomumab. The mechanism of combination therapy was analyzed and biomolecular markers for potential efficacy prediction were screened by detection of lymphocyte subsets, cytokines and metabolomics in peripheral blood.

Description:

Group A(6 patients):patients were subcutaneously injected with 120mg desomumab, and on the second day after injection, the metastatic lesions were treated with hypofractioniated radiotherapy (8Gy×3F or 5Gy×3F), and subcutaneously injected with GM-CSF(200 μg/d) for 7 days, followed by IL-2 (2 million IU/d) for 7 days,and a 200mg PD-1 inhibitor administered within one week after completion of radiotherapy. The course was repeated every 28 days for 2-4 cycles.After combination therapy, maintenance therapy with PD-1inhibitor and desomumab was administered until disease progression or unacceptable toxicity.

Group B(6 patients):patients were treated with hypofractioniated radiotherapy (8Gy×3F or 5Gy×3F), and subcutaneously injected with GM-CSF(200 μg/d) for 7 days, followed by IL-2 (2 million IU/d) for 7 days.On the second day after radiotherapy, 200mg pd-1 inhibitor was administered. After treatment, 120mg desomumab was subcutaneously injected. The course was repeated every 28 days for 2-4 cycles.After combination therapy, maintenance therapy with PD-1inhibitor and desomumab was administered until disease progression or unacceptable toxicity.

The phase II study followed the treatment modality of the cohort with higher safety and efficacy assessments in the Phase I study and additional 39 patients were added.The primary endpoint is disease control rate. Secondary endpoints were objective response rate (ORR), median progression-free survival (PFS), overall survival (OS), and incidence of adverse events

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 51
• Est. completion date: August 15, 2025
• Est. primary completion date: August 15, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Aged=18 years

2. The patients must conform to the advanced solid cancer with multiple metastases(may be accompanied by metastasis of other organs),progression after first-line systemic therapy and have clear pathological diagnosis report

3. The hematopoietic function and general condition of the patients were acceptable(white blood cells >2.5×10^9/L,lymphocyte>0.5 times of normal lower limit,Platelets>50×10^9/L)

4. There was no history of serious hematopoietic function, abnormal heart, lung, liver, kidney function and immune deficiency

5. One week before enrollment,absolute value of T lymphocytes=0.5 times of normal lower limit,neutrophil = 1.0×109/L,AST and ALT =3.0 times normal upper limit(Liver cancer/liver metastasis patients =5.0 times normal upper limit);creatinine = 3.0 times normal upper limit;serum calcium=2.0mmol/L

6. Patients's activity status was assessed by Eastern Cooperative Oncology Group(ECOG) score of 0-3,and life expectancy of more than 3 months

7. Abide by the plan during the study period

8. Sign written consent

Exclusion Criteria:

1. Pregnant or lactating women

2. Patinets diagnosed with other malignant disease in the past five years,except for cured skin cancer and cervical carcinoma in situ

3. The clinical severity of uncontrolled epilepsy,central nervous system disease or mental disorder may hinder the signing of informed consent or affect the patient's compliance with medication

4. Sever(i.e. active)heart disease,such an symptomatic coronary heart disease,New York Heart Association(NYHA) class ? or more severe congestive heart failure or severe arrhythmia requiring drug intervention,or a history of myocardial infraction in the last 12 months;

5. Organ transplantation require immunosuppressive therapy

6. Major active infections are known,or other serious uncontrolled concomitant diseases;endocrine or metabolic disorders,or other serious uncontrolled concomitant diseases;

7. The baseline blood routine did not meet the following criteria:hemoglobin=90g/L;absolute neutrophil count(ANC)=1.5×109/L;platelet=50×109/L;ALT,AST=2.5 times normal upper limit value;ALP=2.5 times normal upper limit value; serum total bilirubin<1.5 times normal upper limit value;Serum creatinine <3 times normal upper limit value;serum albumin=30g/L;

8. Anaphylaxis to any research drug ingredients

9. Patients with a history of immunodeficiency,including HIV postive or with other acquired or congenital immunodeficiency disorders,or with a history of organ transplantation,or with other immune-related diseases requiring long-term oral hormone therapy

10. In the period of acute and chronic tuberculosis infection (T-spot test positive,chest X-ray suspicious tuberculosis focus patients)

11. Researchers considered that it was not suitable for other situations in the group

Related Conditions & MeSH terms

• Metastatic Solid Tumor
• Neoplasms

Intervention

Drug:
• Denosumab
Denosumab 120mg was subcutaneously administered one day before the commencement of radiotherapy or after the PraG treatment every 28 days

Locations

Country	Name	City	State
China	The Second Affiliated Hospital of Soochow University	Suzhou	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Second Affiliated Hospital of Soochow University

Country where clinical trial is conducted

China, 

References & Publications (1)

Kong Y, Ma Y, Zhao X, Pan J, Xu Z, Zhang L. Optimizing the Treatment Schedule of Radiotherapy Combined With Anti-PD-1/PD-L1 Immunotherapy in Metastatic Cancers. Front Oncol. 2021 Mar 30;11:638873. doi: 10.3389/fonc.2021.638873. eCollection 2021. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Does limiting toxicity(CTC 5.0)		phase 1 (1 year)
Primary	DCR	CR+PR+SD(RECIST 1.1)	phase 2 (18 months)
Secondary	objective response rate		after 12-weeks treatment
Secondary	progression-free survival		after 12-weeks treatment
Secondary	overall survival		after 12-weeks treatment
Secondary	incidence of skeletal related events		phase 1/2 (30 months)
Secondary	toxic response		phase 2 (18 months)

External Links

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