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Clinical Trial Summary

This is a Phase I/II trial of the combination pegylated IFN-alpha 2b with ixazomib in metastatic renal cell carcinoma (mRCC). Researchers believe that by disabling the protein complex NF-kB, which controls the transfer of genetic information; using the study drug Ixazomib, they can promote necrotic cell death of RCC using interferon alpha - 2b. They hypothesize that the combination of ixazomib with IFN will lead to increased necrotic cell death in RCC tumors and consequent clinical benefit to patients.

Patients will receive ixazomib capsules and pegylated IFN alfa 2b injection in this research study. Treatments will be given weekly and 4 weeks of treatment make up one cycle.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02447887
Study type Interventional
Source Fox Chase Cancer Center
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date August 14, 2015
Completion date April 25, 2017

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