Metastatic Melanoma Clinical Trial
Official title:
A Phase 1/2 Study to Assess the Safety and Efficacy of Intratumoral IMO-2125 in Combination With Ipilimumab or Pembrolizumab in Patients With Metastatic Melanoma (ILLUMINATE-204)
The goal of the Phase 1 study was to find the recommended Phase 2 dose of the study drug IMO-2125 (tilsotolimod) that can be given in combination with ipilimumab (ipi) or pembrolizumab (pembro) to participants with metastatic melanoma and assess the safety, tolerability, pharmacokinetics (PK), and immunogenicity when administered in combination with ipilimumab or pembrolizumab.
The open-label single-arm Phase 2 study was designed to assess the recommended dose for safety, tolerability, pharmacokinetics (PK), immunogenicity, and efficacy of 8 mg IMO-2125 (tilsotolimod) when administered in combination with ipilimumab. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
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Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma
|
Phase 3 | |
| Active, not recruiting |
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Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma
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Phase 1 | |
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Phase 1 | |
| Active, not recruiting |
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Phase 1 | |
| Completed |
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Aldesleukin in Participants With Metastatic Renal Cell Carcinoma or Metastatic Melanoma
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Phase 4 | |
| Completed |
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Phase 1 | |
| Completed |
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Phase 1 | |
| Recruiting |
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Phase 2 | |
| Active, not recruiting |
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Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma
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Phase 2 | |
| Active, not recruiting |
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Study Comparing TIL to Standard Ipilimumab in Patients With Metastatic Melanoma
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Phase 3 | |
| Active, not recruiting |
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Study of Lifileucel (LN-144), Autologous Tumor Infiltrating Lymphocytes, in the Treatment of Patients With Metastatic Melanoma
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Phase 2 | |
| Terminated |
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Phase 1/Phase 2 | |
| Completed |
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A Translational Systems Medicine Approach to Provide Predictive Capacity for Therapy Response in Advanced or Metastatic Malignant Melanoma
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| Withdrawn |
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Phase 1/Phase 2 | |
| Withdrawn |
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Phase 2 | |
| Terminated |
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Phase 2 | |
| Completed |
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Phase 2 | |
| Completed |
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Phase 2 | |
| Terminated |
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Disulfiram Plus Arsenic Trioxide In Patients With Metastatic Melanoma and at Least One Prior Systemic Therapy
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Phase 1 | |
| Recruiting |
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Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma
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Phase 4 |