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Circulating Tumor Cells and Melanoma: Comparing the EPISPOT and CellSearch Techniques

Metastatic Melanoma Clinical Trial

Official title:
Circulating Tumor Cells and Melanoma: Comparing the EPISPOT (EPithelial ImmunoSPOT) and CellSearch Techniques

Clinical Trial Summary

The main objective of this study is to compare results for the detection of circulating melanoma cells (CMC) using CellSearch versus EPISPOT (EPithelial ImmunoSPOT) techniques between a group of patients with metastatic melanoma and a group of hospitalized control patients.

Clinical Trial Description

The secondary objectives of this study include:

A. To compare the following elements between the two patient groups:

- the number of CMCs per ml of blood as determined by EPISPOT

- the number of CMCs per ml of blood as determined by CellSearch

- the percentage of patients with at least 2 CMCs per ml of blood according to the two techniques

- the % of CMCs expressing KI67

- the % of CMCs expressions S100 (only the EPISPOT technique)

B. To compare the EPISPOT and CellSearch techniques is terms of the following:

- the number of CMCs detected per ml blood

- the number of CMCs expressing antigen KI67

C. To re-evaluate the 2-CMC per ml blood threshold ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01558349
Study type Observational
Source Centre Hospitalier Universitaire de Nimes
Contact
Status Completed
Phase
Start date June 27, 2013
Completion date June 27, 2017
View Details
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