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Clinical Trial Summary

This is a prospective, single-arm, phase II clinical trial that will enroll metastatic colorectal cancer patients with Cetuximab-Related Skin Toxicity, who will receive crisaborole ointment twice daily.


Clinical Trial Description

The efficacy of cetuximab has been demonstrated in treating metastatic colorectal cancer (mCRC). Skin toxicities, especially acneiform eruption, are the major side effects associated with cetuximab, which affect patients' quality of life and can lead to treatment discontinuation and cetuximab dose reduction. This prospective, single-arm, phase II clinical trial aims to explore the efficacy and safety of crisaborole ointment in Cetuximab-Related Skin Toxicity. A total of 33 mCRC patients with acneiform eruption will be enrolled. All of the participants will receive crisaborole ointment twice daily. The total follow-up time is 12 weeks. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06118047
Study type Interventional
Source Sun Yat-sen University
Contact Weiwei Xiao
Phone +8613710390520
Email xiaoww@sysucc.org.cn
Status Recruiting
Phase Phase 2
Start date August 1, 2023
Completion date December 31, 2025

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