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Phase I / II Study of Enadenotucirev by Sub-acute Fractionated IV Dosing in Cancer Patients — EVOLVE  

Metastatic Colorectal Cancer Clinical Trial

Official title:
A Clinical Study Of Enadenotucirev Administered by Sub-Acute Fractionated Intravenous Injection: Dose Escalation in Metastatic Epithelial Solid Tumours and Randomised Controlled Trial in Metastatic Colorectal Cancer

Clinical Trial Summary

This is a multicentre, open-label, Phase I/II study of enadenotucirev in patients with either solid tumour of epithelial origin not responding to standard therapy or for whom no standard treatment exists (Phase I dose escalation stage Single cycle), mCRC not responding to standard therapy (Phase I dose escalation Repeat cycle cohort expansion stage ), mCRC not responding to standard therapy or advanced or metastatic bladder cancer not candidate for chemotherapy (Phase Ib) or mCRC in stable disease or partial response after 3-4 months of first line standard of care chemotherapy (Phase II).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02028442
Study type Interventional
Source PsiOxus Therapeutics Ltd
Contact
Status Completed
Phase Phase 1/Phase 2
Start date September 20, 2012
Completion date April 29, 2016
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