Treatment of Metastatic Cancer in Terminally Diagnosed NCT05491928

Clinical Trial Details — Status: Available

Administrative data
NCT number	NCT05491928
Other study ID #	MBI-23-01
Secondary ID
Status	Available
Phase
First received
Last updated

Study information
Verified date	August 2022
Source	Matrix Biomed, Inc.
Contact	Benji Crane
Phone	6264376506
Email	bjcrane[@]matrixbiomed.com
Is FDA regulated	No
Health authority
Study type	Expanded Access

Clinical Trial Summary

The objective is to provide terminally diagnosed patients with a last line of treatment while improving overall quality of life. Tempol can be added to any chemotherapy regimen to potentially reduce side effects and overcome chemoresistance.

Description:

The objective is to provide terminally diagnosed patients assigned to palliative care and palliative chemotherapy a last line treatment with Tempol. In vivo studies have shown Tempol to work synergistically with a number of chemotherapy agents increasing treatment response and reducing chemoresistance. Additionally, Tempol has been shown to provide protection to non-cancerous cells allowing for increased chemotherapy dosing by reducing side effects. Tempol inhibits HIF-1/VEGF among others in cancerous cells while upregulating GSH/NrF2 among others in non-cancerous cells.

Recruitment information / eligibility
Status	Available
Enrollment	0
Est. completion date
Est. primary completion date
Accepts healthy volunteers
Gender	All
Age group	N/A and older
Eligibility	Inclusion Criteria: - metastatic terminally diagnosed cancer Exclusion Criteria: -

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Tempol
Tempol will be given as an adjunct to chemotherapy.

Locations
Country	Name	City	State
United States	UCHealth University of Colorado Cancer Center - Anschutz Medical Campus	Aurora	Colorado

Sponsors *(1)*
Lead Sponsor	Collaborator
Matrix Biomed, Inc.

Country where clinical trial is conducted

United States,

References & Publications (1)

Ravizza R, Cereda E, Monti E, Gariboldi MB. The piperidine nitroxide Tempol potentiates the cytotoxic effects of temozolomide in human glioblastoma cells. Int J Oncol. 2004 Dec;25(6):1817-22. — View Citation

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Treatment of Metastatic Cancer in Terminally Diagnosed Patients

Clinical Trial Details — Status: Available

Administrative data

Study information