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Clinical Trial Summary

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 in combination with TNO155 in patients with advanced solid tumors that have a KRAS G12C mutation.


Clinical Trial Description

This study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 in combination with TNO155 in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 is an orally available small molecule inhibitor of KRAS G12C and TNO155 is a selective, orally bioavailable allosteric inhibitor of wild-type SHP2. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04330664
Study type Interventional
Source Mirati Therapeutics Inc.
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date April 22, 2020
Completion date December 24, 2024

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