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Clinical Trial Summary

The purpose of this study is to test the safety and efficacy of OMP-336B11. OMP-336B11 is an engineered human protein that was designed to bind to the GITR receptor on T cells and activate the immune system to recognize and eliminate cancer cells.


Clinical Trial Description

This is an open-label, Phase 1a dose escalation study of OMP-336B11 administered as a single agent to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics in patients with locally advanced or metastatic tumors. This study consists of a screening period, a treatment period, and a post-treatment follow-up period in which patients will be followed for survival for up to approximately 2 years. Patients will be enrolled in two stages: a dose-escalation stage and an expansion phase. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03295942
Study type Interventional
Source Mereo BioPharma
Contact
Status Terminated
Phase Phase 1
Start date September 12, 2017
Completion date July 4, 2019

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