Metastases Clinical Trial
Official title:
Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients With Colorectal Liver Metastases
A prospective, interventional study evaluating the safety of Y-90 TARE for tumor control of the right side and induction of left liver hypertrophy as part of a planned single-stage or two-stage hepatectomy for patients with CLM and insufficient FLR at the time of presentation.
Primary Objective: To examine the safety and feasibility of Y-90 TARE directed to the right hemi-liver for induction of left liver FLR hypertrophy as part of a planned hepatectomy for patients with CLM. Secondary Objectives: - To describe changes in liver volume after Y-90 TARE, including: - The kinetic growth rate (KGR) of the FLR - Degree of hypertrophy 6 weeks after TARE - Atrophy of targeted right hemi-liver from TARE date to date of surgery - To describe additional interventional procedures needed to induce additional hypertrophy if insufficient hypertrophy from Y-90 TARE - To assess the proportion of TARE patients who undergo attempted and complete curative-intent resection of CLM - To assess measures of disease control, including: - Tumor marker trend - RECIST/mRECIST criteria - CT morphologic response - PET CT response - To describe Patient Reported Outcomes using MDASI-GI - To assess FLR liver quality, right-sided surgical adhesions from TARE intraoperatively - To describe dosimetry of individual liver lesions - using SPECT/CT, CT, and pathology correlation - To describe change in liver function measured by the pre- and post-TARE HIDA SPECT/CT scans and hepatic function blood tests ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02156700 -
Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors
|
N/A | |
| Terminated |
NCT01403324 -
Comparison of Dosimetry After rhTSH or Withdrawal of Thyroid Hormone in Metastatic or Locally Advanced Thyroid Cancer
|
N/A | |
| Completed |
NCT00091832 -
Denosumab (AMG 162) in Bisphosphonate Naive Metastatic Breast Cancer
|
Phase 2 | |
| Completed |
NCT00094653 -
MDX-010 Antibody, MDX-1379 Melanoma Vaccine, or MDX-010/MDX-1379 Combination Treatment for Patients With Unresectable or Metastatic Melanoma
|
Phase 3 | |
| Completed |
NCT00080301 -
Novel Epothilone Plus Capecitabine Versus Capecitabine Alone in Patients With Advanced Breast Cancer
|
Phase 3 | |
| Completed |
NCT00446446 -
PRISM (Panitumumab Regimen In Second-line Monotherapy of Head and Neck Cancer)
|
Phase 2 | |
| Completed |
NCT01678664 -
Everolimus After (Chemo)Embolization for Liver Metastases From Digestive Endocrine Tumors
|
Phase 2 | |
| Completed |
NCT00093080 -
Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1)(COMPLETED)
|
Phase 2 | |
| Completed |
NCT00083720 -
Erbitux (Cetuximab) Given Alone to Patients With EGFR-Negative Metastatic Colon or Rectal Cancer That is Refractory to Chemotherapy
|
Phase 2 | |
| Completed |
NCT00096967 -
A Study to Evaluate Avastin in Patients Treated in a Previous Genentech-Sponsored Cancer Study
|
Phase 3 | |
| Completed |
NCT00097487 -
A Study of Patients With HER2 Gene Amplified Metastatic Breast Cancer Treated With First Line Herceptin and a Taxane
|
N/A | |
| Completed |
NCT00752570 -
A Phase 2, Randomized, Double Blind, Placebo Controlled Study of AMG 386 in Combination With FOLFIRI in Subjects With Previously Treated Metastatic Colorectal Carcinoma
|
Phase 2 | |
| Completed |
NCT00106418 -
A Research Study for Patients With Prostate Cancer
|
Phase 2 | |
| Not yet recruiting |
NCT04825470 -
Liver Transplantation for Unresectable GIST Liver Metastases
|
N/A | |
| Active, not recruiting |
NCT02414269 -
Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin
|
Phase 1/Phase 2 | |
| Terminated |
NCT01759238 -
Chemoradiotherapy for Patients With Oligometastatic Colorectal Cancer
|
Phase 2 | |
| Completed |
NCT00107861 -
Interferon-Beta Gene Transfer (Ad.hIFN-β) as Treatment for Refractory Colorectal Carcinoma With Liver Metastases
|
Phase 1/Phase 2 | |
| Terminated |
NCT00099281 -
DPPE in Combination With Epirubicin and Cyclophosphamide in the Treatment of Breast Cancer
|
Phase 3 | |
| Completed |
NCT00095108 -
Study of Interleukin-21 for Metastatic Malignant Melanoma and Metastatic Kidney Cancer
|
Phase 1 | |
| Completed |
NCT00313872 -
Phase III Trial of DP Followed by FOLFIRI or the Reverse Sequence in Unresectable Gastric Cancer
|
Phase 3 |