Metastases Clinical Trial
Official title:
Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer
This study seeks to identify risk factors associated with the development of a jaw condition seen in patients with cancer treated with certain medications.
The goal of this research is to build an index of risk for estimating an individual's risk
of developing osteonecrosis of the jaw (ONJ). The bisphosphonates are an important
supportive therapy in the care of patients with metastatic bone disease; they are able to
prevent catastrophic events such as fracture and spinal cord compression. However, ONJ has
been associated with the use of the bisphosphonates and ONJ carries significant morbidity.
Presently, there are insufficient data to calculate the ONJ risk benefit ratio of
bisphosphonate use. An ONJ risk assessment tool would improve both the oncologist's and the
dental health professional the ability to anticipate and potentially mitigate oral
toxicities from bisphosphonate therapy.
This protocol consists of a case (ONJ) control (no ONJ) study to identify factors associated
with the risk of ONJ and to build an index predictive of an individual's risk of developing
ONJ. The index of ONJ risk will be comprised of clinical, epidemiologic and genetic factors
;
Observational Model: Case Control, Time Perspective: Retrospective
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