Metabolomics Clinical Trial
Official title:
Study on the Effect of Conventional General Anesthesia and Mechanical Ventilation on Plasma Small Molecule Metabolites in Patients With Colorectal Cancer Resection
As a newly developed subject, metabolomics can detect accurately and quantitatively small
molecule metabolites such as proteins, carbohydrates and lipids from plasma, tissue and even
single cell, which aims to analyze systemic dynamic change during physiological and
pathological processes, and thus reveals certain reactions that whole organism responds to
specific stimulation.
Colorectal cancer is one of common gastrointestinal tumors, whose morbidity rate tends to
increase in recent years for modern diet and life style, and colectomy serves as one standard
treatment for it. Under total stimulation of surgical operation, general anesthesia and
mechanical ventilation, a series of stress reactions happen complicatedly to colorectal
patients during anesthesia-ventilation process. Without timely recognition and management of
adverse reactions, side effects like hypoxemia, hemorrhage, inflammation, and even death will
happen intraoperatively or postoperatively.
With different metabolomics methods applied to collect, detect and analyze blood samples,
metabolomics provides an innovatory approach to elucidate systemic response during
anesthesia-colectomy process with multi-factors included. By analyzing and comparing dramatic
alteration of small molecule metabolites in colorectal cancer patients' or healthy controls'
plasma in this project, data can reflect the influence of certain disease (colorectal
cancer), anesthetics and mechanical ventilation on colorectal patients with colectomy, which
is helpful for prevention and treatment of intraoperative and postoperative complications.
Nowadays, more and more attention are paid to system biology and its relative techniques,
such as gene sequencing，nuclear magnetic resonance， mass spectrometry and so on. As a newly
developed subject, metabolomics can detect accurately and quantitatively small molecule
metabolites such as proteins, carbohydrates and lipids from plasma, tissue and even single
cell, which aims to analyze systemic dynamic change during physiological and pathological
processes, and thus reveals certain reactions that whole organism responds to specific
stimulation.
Colorectal cancer is one of common gastrointestinal tumors, whose morbidity rate tends to
increase in recent years for modern diet and life style, and colectomy serves as one standard
treatment for it. Under total stimulation of surgical operation, general anesthesia and
mechanical ventilation, a series of stress reactions happen complicatedly to colorectal
patients during anesthesia-ventilation process. Without timely recognition and management of
adverse reactions, side effects like hypoxemia, hemorrhage, inflammation, and even death will
happen intraoperatively or postoperatively.
With different metabolomics methods applied to collect, detect and analyze blood samples,
metabolomics provides an innovatory approach to elucidate systemic response during
anesthesia-colectomy process with multi-factors included. By analyzing and comparing dramatic
alteration of small molecule metabolites in colorectal cancer patients' or healthy controls'
plasma in this project, data can reflect the influence of certain disease (colorectal
cancer), anesthetics and mechanical ventilation on colorectal patients with colectomy, which
is helpful for prevention and treatment of intraoperative and postoperative complications.
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