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Effects of Fructose and Exercise on Hepatic Lipid Metabolism — FRUCTEXER  

Metabolism Clinical Trial

Official title:
Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism

Clinical Trial Summary

8 healthy male volunteers will be studied each on 3 occasions, ie

- after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity

- after 4 days on a weight maintenance diet containing 30% fructose + low physical activity

- after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01121003
Study type Interventional
Source University of Lausanne
Contact
Status Completed
Phase N/A
Start date May 2010
Completion date October 2011
View Details
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