Metabolic Syndrome Clinical Trial
— (META-MORE)Official title:
Metabolic Risk Factors and Myocardial Oxygenation Reserve (META-MORE)
NCT number | NCT05574153 |
Other study ID # | 2021-7267 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | June 30, 2021 |
Est. completion date | December 30, 2024 |
The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.
Status | Recruiting |
Enrollment | 75 |
Est. completion date | December 30, 2024 |
Est. primary completion date | December 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: Patient Participants: - Age 18-80 - Informed Consent - Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels) Healthy Volunteers: - Age 18-80 - No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system - No Smoking Exclusion Criteria: - General MRI contraindications* - Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy. - Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam |
Country | Name | City | State |
---|---|---|---|
Canada | The Reseach Institute of the McGill University Health Centre | Montréal | Quebec |
Lead Sponsor | Collaborator |
---|---|
McGill University Health Centre/Research Institute of the McGill University Health Centre |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Global and segmental Myocardial oxygenation reserve (MORE) | A t-test will be used to assess the difference in global and segmental MORE, at rest, during hyperventilation, and throughout breath hold, between healthy and volunteers and MetS patients. | Baseline | |
Primary | Relation between Breathing maneuver induced MORE and known MetS risk factors. | A linear regression will assess the relation between Breathing maneuver induced MORE and known MetS risk factors, biomarkers, and time since diagnosis. | Baseline |
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