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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05306613
Other study ID # 201912HM107
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date December 30, 2020
Est. completion date March 1, 2023

Study information

Verified date April 2024
Source National Taiwan Normal University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary lean adults.


Description:

Two trials are included - Prolonged sitting and Breaking sitting. In the Prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min. In the Breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. Blood samples were collected in a regular pattern throughout the trials. Energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.


Recruitment information / eligibility

Status Completed
Enrollment 13
Est. completion date March 1, 2023
Est. primary completion date March 1, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 45 Years
Eligibility Inclusion Criteria: - Physical inactive males and females - Aged between 20 and 45 years - Lean healthy (waist circumference less than 90 cm for males and 80 cm for females) - Weight stable for more than 3 months (no change in weight +/- 3%) - Non-smoker - Able to walk comfortably on a treadmill Exclusion Criteria: - Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia - Waist circumference > 90 cm for male and > 80 cm for female - Taking medications that may influence lipid or carbohydrate metabolism or immune system function - Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Prolonged sitting
After consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min.
Breaking sitting
After consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min.

Locations

Country Name City State
Taiwan National Taiwan Normal University Taipei

Sponsors (1)

Lead Sponsor Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Gut hormones responses Changes in blood gut hormones responses (e.g., GLP-1, PYY and GIP concentrations measured in pmol/L) between trials 320 minutes
Secondary Visual analogue scale (VAS) Changes in VAS from 0-100 mm (e.g., appetite and mood, etc.) between trials 320 minutes
Secondary Energy intake Changes in energy intake (e.g, using a food diary to record) after leaving the laboratory until midnight 600 minutes after leaving the laboratory
Secondary Physical activity level Changes in physical activity level (e.g., using an accelerometer to record) after leaving the laboratory until midnight 600 minutes after leaving the laboratory
Secondary Lipid profile Changes in blood lipid profile (e.g., TAG and cholesterol, etc.) between trials 320 minutes
Secondary Blood pressure Changes in blood pressure (systolic and diastolic blood pressure) between trials 320 minutes
Secondary Computerized cognitive testing Changes in cognitive function (e.g., accuracy and reaction time) between trials 320 minutes
Secondary Incremental area under curve (iAUC) for metabolic health Changes in incremental area under curve (iAUC) for insulin and glucose between trials 320 minutes
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