Metabolic Flexibility Clinical Trial
Official title:
Employing Dynamic Kinetic Responses to Demonstrate the Effectiveness of Dietary Intervention: A Challenge-based Study Using a Low-glycaemic Load Diet
This study is testing the effectiveness of a dietary intervention by means of measuring the
change in RQ upon a hyperinsulinemic euglycemic clamp challenge and by means of measuring the
kinetic responses of multiple PF markers (including RQ) to an acute mixed meal challenge
before and after a 6-week dietary intervention. The challenges will be applied to investigate
whether the kinetic response is a better measure for health and wellbeing when compared to
fasting (baseline) levels. In addition, several measures that reflect perceivable benefits
like mood, quality of life, sleep quality, cognitive and physical performance will be
assessed in a first exploratory attempt to link (changes in) PF to consumer perceivable
benefits.
Subjects will be randomly allocated to a low glycemic load diet or a 'Western' diet for 6
weeks. Before and after the intervention several measurements will take place. The low
glycemic load diet will be high in polyphenols, protein, vegetables, pulses, fibres and nuts,
and low in glycemic carbohydrates. All these dietary factors have been shown to improve
glycemic control and/or to reduce metabolic syndrome risk factors.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04773132 -
Human Metabolic Flexibility: Its Role in Energy Regulation and Obesity
|
N/A | |
| Completed |
NCT05282355 -
Astaxanthin Reduces Exercising Heart Rate.
|
N/A |