The Influence of Different At-home Exercise Strategies on 24h Glycemic Control

Metabolic Disturbance Clinical Trial

Official title:

The Influence of Different At-home Exercise Strategies on 24h Glycemic Control in Women at Risk for With Metabolic Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05490706
• Other study ID #: 42756-2
• Status: Completed
• Phase: N/A
• Start date: July 7, 2022
• Est. completion date: April 30, 2023

Study information

• Verified date: May 2023
• Source: University of Toronto
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will determine how different at-home exercise strategies influence 24hr glycemic control in women with metabolic dysfunction.

Description:

Elevations in blood glucose concentration increase risk for cardiometabolic diseases including type 2 diabetes and cardiovascular diseases. Exercise can improve glycemic control, but there is limited research comparing the effectiveness of different exercise strategies in women. The aim of this study is to examine, under free-living conditions, how performing either walking and bodyweight interval exercise after dinner influences glycemic control in women with or at risk for type 2 diabetes. Glycemic control will be measured with continuous glucose monitors.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 107
• Est. completion date: April 30, 2023
• Est. primary completion date: April 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• Females

• no cancer history

• =50 years old

• Have metabolic dysfunction (defined as self-reported diagnosis of pre-diabetes, type 2 diabetes, or at least moderate Canadian diabetes risk (CANRISK) score)

• Owns a smartphone with Bluetooth capability with Apple or Android operating system

• deemed safe to exercise as per the CSEP Get Active Questionnaire

• Enrolled in NCT05454943

Exclusion Criteria:

• Type 1 diabetes

• Taking exogenous insulin, sulfonylureas, or GLP-1 receptor agonists

• Self-reported history of an eating disorder

• BMI <18.5 kg/m

• Working night or rotating shifts

• Eating window <12 hours or consistently eating less than 3 meals/day in the past 3 months

• Major dietary changes within the past 3 months (i.e. calorie counting, ketogenic diet)

Related Conditions & MeSH terms

• Metabolic Disturbance

Intervention

Behavioral:
• Bodyweight interval exercise
Performing 15 minutes of bodyweight interval exercise after dinner at home by following a video
• Walking
Performing a 30 minute minute walk after dinner at home

Locations

Country	Name	City	State
Canada	University of Toronto	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
University of Toronto

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	24hr Glucose area under the curve	Glucose area under the curve over 24hr	24 hours
Secondary	24hr Average glucose concentration	Average glucose concentration over 24 hr	24 hours
Secondary	Postprandial dinner glucose response	Measured as the 2hr postprandial glucose incremental area under the curve (iAUC), average glucose and peak glucose	2 hours
Secondary	Postprandial breakfast glucose response	Measured as the 2hr postprandial iAUC, average glucose and peak glucose	2 hours
Secondary	Postprandial lunch glucose response	Measured as the 2hr postprandial glucose iAUC, average glucose and peak glucose	2 hours
Secondary	Nocturnal glucose	Measured as the overnight glucose average and AUC	~6-8 hours
Secondary	Time in hyperglycemia	Time (minutes and percent per day) above 10mmol/L over 24hr	24 hours
Secondary	Time in hypoglycemia	Time (minutes and percent per day) under 3.9mmol/L over 24 hr	24 hours
Secondary	Time in range	Time (minutes and percent per day) above 3.9 but under 10mmol/L	24 hours
Secondary	Continuous overall net glycemic action (CONGA)	Calculated measure of glycemic variability	24 hours
Secondary	Change in glucose during exercise	Post vs. pre glucose concentration around exercise	15-30 minutes
Secondary	Mean amplitude glycemic excursion (MAGE)	Calculated measure of glycemic variability	24 hours
Secondary	Standard deviation (SD)	Calculated measure of glycemic variability	24 hours
Secondary	% coefficient of variation (CV)	Calculated measure of glycemic variability	24 hours