Glycemic Response of Co-ingesting Carbohydrate and Amino Acids

Metabolic Diseases Clinical Trial

Official title:

Glycemic Response of Co-ingesting Carbohydrate and Amino Acids

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02455765
• Other study ID #: 2014/00366
• Status: Completed
• Phase: N/A
• First received: May 21, 2015
• Last updated: January 27, 2016
• Start date: June 2014
• Est. completion date: October 2015

Study information

• Verified date: January 2016
• Source: Clinical Nutrition Research Centre, Singapore
• Contact: n/a
• Is FDA regulated: No
• Health authority: Singapore: Domain Specific Review Boards
• Study type: Interventional

Clinical Trial Summary

The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).

Description:

Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: October 2015
• Est. primary completion date: October 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 21 Years to 50 Years

Eligibility

Inclusion Criteria:

• Male

• Chinese ethnicity

• Age between 21-50 years

• Body mass index (BMI) between 18-24.9 kg/m2

• Waist circumference = 90 cm for men

• Normal blood pressure (<120/80 mmHg)

• Fasting blood glucose < 6 mmol/L

Exclusion Criteria:

• dislike the consumption of Essence of Chicken

• participating in competitive sports

• allergic to amino acids and rice

• metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)

• Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency

• on prescription medication

• smokers

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Metabolic Diseases

Intervention

Other:
• Rice and Amino Acid mixtures
Rice and amino acid mixture

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Clinical Nutrition Research Centre, Singapore	Cerebos Asia Pacific Pte Ltd

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glycemic response	Blood glucose will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min	210 minutes post consumption of carbohydrate	No
Primary	Insulinemic response	Plasma insulin will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min	210 minutes post consumption of carbohydrate	No