Metabolic Diseases Clinical Trial
Official title:
The Metabolic Effects of Consuming Carbohydrate With Different Protein Types
Verified date | May 2019 |
Source | Clinical Nutrition Research Centre, Singapore |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study aims to find out how consuming different proteins with rice affect metabolism. Most meals the investigators eat predominantly consist of a carbohydrate and protein (i.e. rice, noodles, bread etc with meats or seafood). However, it is still unknown how consuming different proteins with commonly eaten carbohydrates affect metabolism. Previous studies have shown that proteins stimulate hormones such as insulin, glucagon and gut hormones. However, the extent of the response depends on protein type. The metabolic responses to carbohydrates have also been shown to be greatly affected when they are eaten with proteins. However, most of the previous studies have used glucose as the carbohydrate and it is still unknown how eating proteins with carbohydrate foods such as rice affect metabolism. Therefore, this study has been initiated to determine the metabolic effects of eating different protein types with rice. Using the most common carbohydrate eaten in Asia (rice) and four commonly eaten protein foods (egg, chicken, fish and beancurd), this study aims to observe the metabolic effects of co-ingesting proteins and carbohydrate. The resulting data will provide valuable insights into the metabolic effects of protein-carbohydrate meals and will be useful in the development of practical advice and dietary guidelines for those with chronic diseases (such as diabetes and obesity).
Status | Completed |
Enrollment | 15 |
Est. completion date | October 8, 2018 |
Est. primary completion date | October 8, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 21 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Chinese ethnicity - Male - Age between 21-40 years - Do not have any metabolic diseases (diabetes, hypertension etc) - Do not have G6PD deficiency - Not on prescription medication known to affect glucose related metabolism - Not allergic/intolerant to any of the test foods - Do not partake in sports at the competitive and/or endurance levels - Weight of at least 45kg - Body mass index between 18.0 to 24.9 kg/m2 - Normal blood pressure (120/80 mmHg) - Fasting blood glucose <6.0 mmol/L |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Clinical Nutrition Research Centre, Singapore |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood glucose response (incremental area under the curve) measured using the hemocue | Blood glucose response (incremental area under the curve) measured using the hemocue | 3.5 hours post consumption | |
Primary | Insulin (incremental area under the curve) is determined using the COBAS | Insulin (incremental area under the curve) is determined using the COBAS | 3.5 hours post consumption | |
Primary | Glucagon determined using the ELISA | Glucagon is determined using the ELISA | 3.5 hours post consumption | |
Secondary | Effects of physical activity | Self-reported evaluation of physical activity according to a qualitative scale: light, medium or strenuous exercise done the day before the study visit. | Assessed at the start of every test session 1-2 weekly and up to 8 weeks in total per subject. | |
Secondary | Satiety: Hunger and fullness measured using the Visual analogue scale | Hunger and fullness measured using the Visual Analogue Scale | Assessed at the start of every test session 1-2 weekly and up to 8 weeks in total per subject. |
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