Metabolic Diseases Clinical Trial
Official title:
Etude Des Troubles métaboliques Induits Par Une Course à Pied très Longue Distance, " La Diagonale Des Fous " de La Réunion / Metabolic Disorders in Ultramarathon Runners of the Madmen's Diagonal Race on Reunion Island
Acute consequences of ultramarathon running are still unknown as very little research has been done on the matter. The investigators will assess the consequences on the metabolism of runners in the ultramarathon Madmen's Diagonal on Reunion Island. Data from the literature suggest that runners undergo loss of zinc, copper, iron, magnesium not unlike the loss of metabolites in systemic inflammatory response syndrome. The purpose of this study is to assess the metabolic disorders (selenium, zinc, vitamins B9 and B12) in ultramarathon runners, during and up to 28 days after the Madmen's Diagonal which takes place on Reunion Island every year in October.
Ultramarathons are races involving walking or running longer than the traditional marathon
length of 42km and frequently take longer than 12 hours to complete. These races are
increasingly frequent and racers attempt to push back the limits of what their body can
accomplish. However, these races are not without certain risks.
The Reunion Island Grand Raid (or Madmen's Diagonal) is one such race, crossing the island
over 163 km (101 mi) with an altitude gain of 9,643 meters (31,637 ft). Temperatures vary
from 0 et 30 degrees Celsius (32-86°F) and the race can take 27 to 67 hours to complete.
About 40% of the racers do not cross the finish line. Each year, two or three racers are
hospitalized each year in the intensive care unit (ICU) for tubular necrosis and treated
with dialysis. Scientific literature shows that racers can present acute rhabdomyolysis,
with elevated levels of CPK-MB. Nevertheless, there have been very few studies on the impact
of these ultramarathon racers on other biological parameters. As the racers compete and lose
about a liter of sweat every hour, they also lose ions and trace metals such as zinc,
copper, iron, magnesium, which can have major repercussions during and after the race. These
losses are akin to those observed in severe burn victims. In these patients, it has been
shown that supplementation in trace elements can decrease mortality and hospitalization
time.
Moreover, a major inflammatory response has been observed in racers who compete in
ultramarathons. This inflammatory response is similar to that of the systemic inflammatory
response syndrome (SIRS). Patients in the ICU who are septic or who present a SIRS also have
metabolic diseases, and it has been shown that selenium levels are a prognostic factor of
SIRS and supplementation can increase survival rates.
Investigators present the hypothesis that ultramarathon racers can have decreased levels of
selenium and other ions and trace metals and that specific supplementation can limit risks
and improve recovery. More specifically, investigators suggest that selenium levels will
decrease by 25% after the race and remain so at least a week.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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