Resistance Exercise, Metabolism and Time of Day

Metabolic Disease Clinical Trial

Official title:

The Impact of the Time of Day on Metabolic Responses to Resistance Exercise in Adults Who Are Obese or Overweight: a Randomised Controlled Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05321914
• Other study ID #: 200210068
• Status: Recruiting
• Phase: N/A
• Start date: May 1, 2022
• Est. completion date: April 1, 2024

Study information

• Verified date: November 2022
• Source: University of Glasgow
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives:

1. Compare the effects of resistance exercise training performed in the morning vs the evening on insulin sensitivity

2. Compare the effects of resistance exercise training performed in the morning vs the evening on gains in muscle mass and strength

3. Compare the acute glucose responses to resistance exercise performed in the morning vs the evening

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 36
• Est. completion date: April 1, 2024
• Est. primary completion date: April 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• pass the physical activity readiness questionnaire

• body mass index (BMI) >27kg/m² and limited to 40 kg/m².

Exclusion Criteria:

• Prior surgery for weight loss

• Prior history of heart, lung, cancer, endocrine or liver disease

• Participating in more than 1 hour structured exercise training per week

Related Conditions & MeSH terms

• Metabolic Disease
• Metabolic Diseases

Intervention

Behavioral:
• Exercise training
Exercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise.

Locations

Country	Name	City	State
United Kingdom	Stuart Robert Gray	Glasgow

Sponsors (1)

Lead Sponsor	Collaborator
University of Glasgow

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in insulin sensitivity	Insulin sensitivity calculated via the Matsuda Index during an oral glucose tolerance test	Change from baseline to 6 weeks
Secondary	Change in vastus lateralis muscle thickness	Muscle thickness of the vastus lateralis muscle measured via ultrasound	Change from baseline to 6 weeks
Secondary	Change in whole body lean mass	whole body lean mass measured via bio-electrical impedance	Change from baseline to 6 weeks
Secondary	Change in whole body fat mass	whole body fat mass measured via bio-electrical impedance	Change from baseline to 6 weeks
Secondary	Change in one-repetition maximum muscle strength	Sum of one-repetition maximum of Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise exercise	Change from baseline to 6 weeks
Secondary	Change in knee extensor maximal isometric torque	Knee extensor maximal isometric torque measured during a maximal voluntary contraction	Change from baseline to 6 weeks
Secondary	Change in grip strength	Grip strength measured with a hand held dynamometer	Change from baseline to 6 weeks
Secondary	Change in mean glucose levels	Mean glucose levels measured via continuous glucose monitors	Change from baseline to 6 weeks
Secondary	Change in glucose variability	Glucose variability measured via continuous glucose monitors	Change from baseline to 6 weeks