Mental Health Clinical Trial
Official title:
The Impact of Cholinesterase Inhibitors on Driving Ability in Healthy Older Adults: A Pilot Study
The goal of the study is to assess the role of cholinesterase inhibitors in affecting the driving ability of cognitively intact seniors using driving simulators. We hypothesize that the use of a cholinesterase inhibitor for two weeks will be associated with improvement in safe driving behavior on a simulated driving task.
Alzheimer's disease (AD) is the most common cause of dementia, and while it is known that AD
poses substantial risks of motor vehicle collisions, many people in the earliest stages of AD
continue to drive. Memory problems themselves are poor predictors of who is actually unsafe
on the road, and various medications that are used to treat people with AD may impact on
their driving abilities. Donepezil is a drug used to treat the memory problems associated
with AD. While previous studies have shown that it slows the decline of activities of daily
living (eg. shopping, banking, dressing) and may improve the ability of younger pilots to
perform on computerized flight simulators, no studies have examined the impact of donepezil
on driving abilities in older adults.
The present investigation is a pilot study aiming to determine if donepezil helps healthy
older drivers perform on driving simulators. Two Canadian academic centers have different
driving simulators - one in Toronto and one in Thunder Bay. At each of these centers, ten
healthy men aged 65 to 75 will be randomly assigned to receive either donepezil 5mg/day or
identical placebo for two weeks.
Using the driving simulator, we will assess various aspects of driving ability. These
measures of driving performance will be compared between those who received the drug and
those who received the placebo.
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