Menstrual Irregularity Clinical Trial
Official title:
"REFUEL" Active Women's Study II: Increased Caloric Intake to Reverse Energy Deficiency in Exercising Women: Impact on Bone and Menstrual Cyclicity
The purpose of this study is to examine the effects of increased food intake on the menstrual cycle and bone health in physically active women who have irregular or absent menstrual cycles. This study will examine whether a 12 month period of increased food intake will cause menstrual cycles to resume and help bones get stronger.
Low levels of estrogen found in physically active, premenopausal women with irregular or
absent menstrual periods is likely caused by insufficient energy (calorie) intake compared
to energy expenditure. Premenopausal women with menstrual disturbances and amenorrhea suffer
from reductions in bone mineral density, particularly in the lumbar spine. Bone loss
observed in amenorrheic women may be serious enough to result in osteoporotic fractures, but
is also associated with a high prevalence of stress fractures. Increased calorie intake
should help improve energy status, menstrual status, and bone health.
Comparison: Premenopausal women with irregular or absent menstrual periods will be assigned
to either receive additional calories or serve as controls. A group of premenopausal women
with normal menstrual periods will also be used for comparison.
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