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Hormonal Replacement Therapy and Small Artery Function — HRT  

Menopause Clinical Trial

Official title:
Hormonal Replacement Therapy and Small Artery Function

Clinical Trial Summary

Endothelial dysfunction in resistance arteries in women after the menopause is important for the development of high blood pressure and cardiovascular disease

Clinical Trial Description

We aim to study the effects of different hormone replacement therapies (HRT) on the function and morphology of resistance arteries, and to look for their mechanistic basis. We expect that HRT with estrogens or in combination with MPA may benefit the function of resistance arteries and may preserve the morphological integrity of endothelial cells by regulatory actions on the cytoskeleton. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00564031
Study type Interventional
Source Karolinska University Hospital
Contact
Status Completed
Phase Phase 3
Start date January 2003
Completion date August 2004
View Details
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