Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients

Meningoencephalitis Clinical Trial

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02207647
• Other study ID #: 12H-770352
• Secondary ID: U01CK000176
• Status: Terminated
• Start date: April 2014
• Est. completion date: December 2021

Study information

• Verified date: April 2022
• Source: Olive View-UCLA Education & Research Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern. Routine clinical and laboratory evaluation of such patients involves screening for known infectious disease agents, selection of which is nonstandardized. Progress in diagnostic technologies, especially molecular techniques based on genetic characteristics of potential pathogens, has greatly expanded the investigators capacity to evaluate specimens from patients for a much wider range of potential pathogens (bacterial, viral, fungal and parasitic agents). Use of Polymerase Chain Reaction (PCR) technology offers the possibility of identifying causative agents for the approximately 50% of all such presentations which go un-diagnosed. The investigators propose a study involving a collaboration between the EMERGEncy ID NET, a network of 10 geographically diverse university-affiliated urban emergency departments (coordinated by Olive View-UCLA Medical Center) and the Centers for Disease Control and Prevention (CDC), to use these new technologies to address this issue.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 1000
• Est. completion date: December 2021
• Est. primary completion date: July 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 3 Months and older

Eligibility

Inclusion Criteria:

• Age > or = 3 months old

• Receiving a Lumbar Puncture in the emergency department as part of their standard care.

Exclusion Criteria:

• No CSF available

Related Conditions & MeSH terms

• Emergencies
• Meningoencephalitis
• Other Syndromes Requiring Lumbar Puncture in Emergency Department

Intervention

Other:
• no intervention

Locations

Country	Name	City	State
United States	Olive View-UCLA Medical Center	Sylmar	California

Sponsors (2)

Lead Sponsor	Collaborator
Olive View-UCLA Education & Research Institute	Centers for Disease Control and Prevention

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	prevalence of pathogens	We will describe the range and proportion of pathogens found in CSF among patients enrolled over a 2 year period.	2 years