Meniere Disease Clinical Trial
Official title:
Metabolic Disorders and Their Correction in Vertigo and Unsteadiness
The purpose of investigation is to assess the levels of metabolic factors (hydroxyvitamin D, homocysteine) between patients with vestibular dysfunction of peripheral origin (BPPV) and central origin (vestibular migraine). Also we will analyse another factors (such as anxiety and depression) and optimize therapeuthical approach accordingly with the data.
Dizziness causes up to 2 to 15% of primary neurological complaints. In some patients who have undergone acute vertigo, postural instability, persistent postural perceptual vertigo (PPPV) develops, while in other similar cases occurs full recovery. So, it is necessary to search for neurophysiological, metabolic and psychophysiological factors and associated premorbid conditions that affect the outcome of neurovestibular compensation. The case-control study will include 2 groups of patients suffering from vertigo of central and peripherial etiology. First group is recruited with patients were diagnosed with peripherial vestibular disorders, such as benign paroxysmal positional vertigo (BPPV), Meniere disease, vestibular neuritis. The proposal number of subjects in the first group is about forty. The second group will consist of forty patients with central vestibular disfunction: vestibular migraine, central positional vertigo etc. The inclusion of patient with persistent postural perceptual dizziness is discussed. Patients will be tested for hydroxyvitamin D and homocysteine in serum using an enzyme-linked immunosorbent assay (ELISA). The perception of the severity of disability was assessed using the Dizziness scale Handicap Inventory (DHI). All patients will undergo psychological test, including tas-26 scale, Beck's Depression Inventory, Spielberg-Hanin'sscale. Statistical analysis was carried out with the Statistical Analysis System (SAS) package. The relationships will be assessed using the chi squared test and logistic regression. The level of significance is set at p < 0.05. The methods for small samples (Mann-Whitney U ) will be used. It is presumed that differences in vitamin D levels beetween two groups will be considerable. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04835688 -
Ventilation Tube Insertion for Unilateral Menière's Disease
|
N/A | |
Recruiting |
NCT05851508 -
The Effecttiveness of Intratympanic Methylprednisolon Injections Compared to Placebo in the Treatment of Vertigo Attacks in Meniere's Disease
|
Phase 3 | |
Not yet recruiting |
NCT05322538 -
Menier's Disease - Bone Density Study
|
N/A | |
Completed |
NCT05328895 -
Transcutaneous Auricular Vagus Nerve Stimulation for Meniere Disease
|
N/A | |
Completed |
NCT04569175 -
Non Enhanced Labyrinth Imaging for the Detection of Endolymphatic Hydrops in Meniere's Disease "NELI Study"
|
N/A | |
Not yet recruiting |
NCT05582148 -
Meniere Disease and Hearing Aids
|
N/A | |
Completed |
NCT05844657 -
Comprehensive Evaluation in Patients With Meniere's Disease
|
||
Completed |
NCT04902963 -
What is the Tympanic Membrane Healing Time After Insertion of a Gelfoam PE Tube?
|
N/A | |
Completed |
NCT04686695 -
Transcutaneous Auricular Vagus Nerve Stimulation Treatment on Meniere Disease
|
N/A | |
Recruiting |
NCT04815187 -
Repurposed Use of Allergic Rhinitis and Allergic Asthma Drug to Reduce Vertigo and Hearing Loss in Meniere's Disease
|
Phase 4 | |
Recruiting |
NCT06278129 -
Evaluation of the Diagnostic and Prognostic Efficacy of MRI in Acute Sensorineural Hearing Loss and Ménière's Disease
|
||
Recruiting |
NCT04766853 -
Verification of the Efficacy/Safety of the Intratympanic Drug Delivery for Hearing Loss
|
Phase 1/Phase 2 | |
Recruiting |
NCT04370366 -
Imaging of Endolymphatic Hydrops at 7T MRI
|
||
Enrolling by invitation |
NCT03520322 -
A Study of a Mastoid Device in Subjects With Ménière's Disease
|
N/A | |
Not yet recruiting |
NCT05424302 -
Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy
|
N/A | |
Withdrawn |
NCT04674735 -
Safety of APSLXR in Patients Presenting Vertigo of Vestibular Origin or Meniere's Disease
|
Phase 1 | |
Recruiting |
NCT03795675 -
CI Following VS Removal or Labyrinthectomy
|
N/A | |
Completed |
NCT04218123 -
Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere's Disease Outcomes
|
Phase 2/Phase 3 | |
Withdrawn |
NCT02371798 -
Unilateral Meniere Disease: Can Double Dose Gadolinium and Delayed Imaging Make the Diagnosis?
|
N/A | |
Completed |
NCT05960786 -
Treating the Symptoms of Vertigo in a Real-world Setting Using the OtoBand
|
N/A |