Electrophysiological Signatures of Distinct Working Memory Subprocesses That Predict Long-term Memory Success

Memory Clinical Trial

— WMLTM  

Official title:

Electrophysiological Signatures of Distinct Working Memory Subprocesses That Predict Long-term Memory Success

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT05892419
• Other study ID #: IRB15-1290
• Status: Enrolling by invitation
• Start date: July 1, 2022
• Est. completion date: July 31, 2026

Study information

• Verified date: June 2023
• Source: University of Chicago
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Healthy young adults will view pictures of items while the investigators record electroencephalogram (EEG) brain activity. Then, the investigators will ask the participants to report which items the participants remember seeing. The investigators will examine how the measured brain activity relates to which pictures the participants remember.

Description:

Electrophysiological signatures track distinct subprocesses of working memory, including the number of items and the spatial locations of those items. By identifying how these subprocesses predict long-term memory success in healthy young adults, this project should lead to an intricate understanding of the relationship between working memory and long-term memory. This study will investigate when and how long-term memory failures arise, by using sophisticated machine learning analyses of neural data. Moreover, this study will test the extent to which the investigators can track working memory processes in real time and how the investigators can leverage that information to improve long-term memory success. This will inform basic theories of the relationship between working memory and long-term memory and motivate future applications.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 96
• Est. completion date: July 31, 2026
• Est. primary completion date: July 31, 2024
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• normal or corrected to normal vision

Exclusion Criteria:

• non-fluent in English

Related Conditions & MeSH terms

• EEG
• Memory

Intervention

Other:
• No intervention
There is no intervention

Locations

Country	Name	City	State
United States	University of Chicago	Chicago	Illinois

Sponsors (1)

Lead Sponsor	Collaborator
University of Chicago

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Memory performance	To measure recognition memory performance, participants will view pictures and respond as to whether they remember previously seeing these items. Participants will be shown both old and new items. In the long-term memory phase, they will report their confidence at having seen each image using a four point rating scale, ranging from being confident the item is new (i.e., not previously seen) to being confident the item is old (i.e., previously seen).	This task is performed multiple time within the experimental session, which in total lasts around 3 hours.