Clinical Trials Logo

Clinical Trial Summary

The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI). The study uses a novel, individualized targeting approach for TMS based on each subject's individual multi-modal fMRI data. The individualized target will be stimulated in a TMS/ fMRI imaging session to investigate working memory states and optimal stimulation frequencies.


Clinical Trial Description

Prior to any study visits, all subjects will be pre-screened through a REDCap online self-report screening REDCap. The study involves 11 study visits. The first study visit will consist of a consenting and extended screening visit. All participants will have the opportunity to ask questions before signing the electronic consent form. We will complete a semi-structured clinical interview and will demonstrate TMS to ensure the participant is comfortable with all study procedures. This visit will be completed both remote and in-person. The second study visit will involve a 1-hour MRI scan. During the scan, the participant will complete multiple computerized tasks. The MRI scan will include both structural and functional scans, and those scans will be used to localize the stimulation target for the subsequent sessions. The third study visit will be a 2-hour TMS/fMRI session, and the participant will engage in behavioral tasks while interleaved rTMS rounds are delivered at different excitatory frequencies (frequency range: 2Hz-20Hz). This scan will be used to determine the optimal stimulation frequency for the individual participant. The fourth, fifth, and sixth study visits will involve neuromodulation with either the optimized frequency or the frequency least successful in moving a participants brain state, as determined from the third study visit. Each subject will receive ~3000 pulses in each session, including the pulses from the motor threshold determination. We will determine the stimulation amplitude by using the Stokes equation, which accounts for differences in cortical distance from the site relative to motor cortex (where the motor threshold is found). The seventh study visit will involve a 1-hour TMS/fMRI session while the participant is engaging in a behavioral task. This visit is designed to examine brain and behavioral changes after the first round of neuromodulation. The seventh and the eighth visit will be scheduled at least one week apart. The eighth, ninth, and tenth study visits will mirror the fourth, fifth, and sixth study visits and will involve neuromodulation with either the optimized or least-optimized individual frequency. The order of optimized and least-optimized frequencies will be counterbalanced across participants between Visit 4-6 and Visit 8-10 (i.e., half of the participants will receive stimulations of the two frequencies in one order, and the other half will receive stimulations of the two frequencies in the reverse order). The eleventh visit will mirror the seventh visit and will examine brain and behavioral changes after the second round of neuromodulation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04402294
Study type Interventional
Source University of Pennsylvania
Contact Almaris Figueroa-Gonzalez
Phone 215-746-6751
Email almaris.figueroa-gonzalez@pennmedicine.upenn.edu
Status Recruiting
Phase N/A
Start date November 24, 2021
Completion date January 31, 2025

See also
  Status Clinical Trial Phase
Completed NCT01007682 - Intrusive Reexperiencing: The Role of Working Memory Capacity and Thought Suppression N/A
Completed NCT04330677 - Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin Phase 1
Active, not recruiting NCT04392908 - Communication Memory of Cancer Diagnosis Within the Pediatric Triangle
Recruiting NCT04694534 - Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients N/A
Completed NCT01159652 - Hypnotic Medications and Memory: Effect of Drug Exposure During the Night Phase 4
Recruiting NCT04598945 - Acquisition and Retention of Motor Memories in Adults and Typically Developing Children N/A
Terminated NCT04021797 - Autonomic Mechanisms of Sleep-dependent Memory Consolidation N/A
Not yet recruiting NCT04103463 - Interactive Stepping Exercise on Memory N/A
Completed NCT04025255 - The Memory and Cognitive Performance Study N/A
Recruiting NCT06351098 - Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition Early Phase 1
Completed NCT06047899 - Influence of Luteolin for Two Weeks on Memory in Healthy Subjects N/A
Completed NCT01126229 - Resveratrol for Improved Performance in the Elderly Phase 1
Completed NCT00913640 - Prospective Memory in Parkinson's Disease
Completed NCT03974399 - BDNF Levels After Bacopa N/A
Completed NCT01143194 - A Randomized, Placebo-Controlled, Double-Blind, Crossover Study to Evaluate the Effects of Three Doses of the Dietary Supplement oréVida™ on Alertness, Attention and Concentration in Healthy Men and Women Phase 1
Completed NCT00454454 - Virtual Reality Helmet to Test for Problems With Memory N/A
Completed NCT00584324 - Depth of Anesthesia on Implicit Memory N/A
Completed NCT06074172 - The Effect of Cannabidiol in Learning and Memory of Adults Phase 2
Completed NCT03763409 - Losartan and Emotional Memory N/A
Completed NCT05907707 - Effects of Gamma-tACS on Memory and Sleep N/A