Efficacy of Cognitive Training in Subjective Memory Impairment

Memory Loss Clinical Trial

Official title:

A Prospective, Three-arm, Parallel Design, Controlled Trial to Assess Efficacy of Cognitive Training in Subjective Memory Impairment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02555774
• Other study ID #: YJeongHong
• Status: Completed
• Phase: N/A
• Start date: May 2014
• Est. completion date: February 2016

Study information

• Verified date: August 2018
• Source: Asan Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.

Description:

Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 65
• Est. completion date: February 2016
• Est. primary completion date: November 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 55 Years to 75 Years

Eligibility

Inclusion Criteria:

• Subjects who showed normal range (above 16percentile of norm) in all domains of detailed neuropsychological tests battery named Seoul Neuropsychological Screening Battery (SNSB)

• Clinical dementia rating (CDR) score of 0

• Subjects with at least 3 years of formal education

Exclusion Criteria:

• Subjects with mild cognitive impairment or dementia

• Subjects who was diagnosed as any neurological disorders such as epilepsy, stroke, hemorrhage, hydrocephalus, Parkinson's disease or brain tumor

• Subjects with uncontrolled severe medical conditions according to investigator's opinion

Related Conditions & MeSH terms

• Memory Disorders
• Memory Loss

Intervention

Behavioral:
• cognitive training
cognitive training is held 2 times a week for 3 months, 90 minutes per 1 session. It includes cognitive exercise of multiple cognitive domains such as memory, attention, calculation, executive function and visuospatial function.
• lifestyle modification
education about lifestyle modification is done by investigators at the first day of the trial and the investigators conduct weekly phone call to participants to educate the lifestyle modifications

Locations

Country	Name	City	State
Korea, Republic of	Jae-Hong Lee	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Asan Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Paired associates learning test	paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.	3 month
Primary	Rapid visual information processing test	rapid visual information processing is a part of computerized neuropsychological test battery named CANTAB. The score is shown as correct response rate.%	3 month
Primary	Pattern recognition memory test	paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The score is shown as correct response rate.%	3 month
Primary	Spatial working memory test	paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.	3 month
Secondary	cognitive failure questionnaire	questionnaire for measuring self reported cognitive status. score range: 0-100. Higher score means worse cognitive status.	3 month
Secondary	Mini-mental state examination	mini-mental state examination that examines general cognition. range 0-20. Higher score means better cognition.	3 month
Secondary	Geriatric depression scale	questionnaire for depression measuring. score range:0-15. lower score means less depression.	3 month
Secondary	Beck anxiety index	questionnaire for self reporting anxiety measuring. range:0-63. low score means less anxiety.	3 month
Secondary	Seoul instrumental activities of daily living	scale for measuring activities of daily living limitation. score range 0-45. low score means better ability.	3 month
Secondary	Rey complex figure copy test	test for visuospatial function. Participants should copy the complex figure. score range: 0-36. Higher score means better visuospatial function.	3 month
Secondary	Digit symbol test	a test for attention and psychomotor speed. Participants are instructed to write an appropriately matched code for each number. Correct number is counted. score range: 0-76. Higher score means better function.	3 month
Secondary	Seoul verbal learning test, immediate recall	measuring tool for immediate memory function. Investigators read 12 words to participants. Participants should remember the words. Tests are done 3 times. score range: 0-36. Higher score means better immediate memory function	3 month
Secondary	Seoul verbal learning test, delayed recall	measuring tool for 20 minutes delayed memory function. After 20 minutes from the immediate recall test, participants should remember the words. score range: 0-12. Higher score means better delayed memory function	3 month
Secondary	Seoul verbal learning test, delayed recall	measuring tool for cued recall of verbal memory function. score range: 0-24. 2. Higher score means better memory recognition function	3 month
Secondary	Logical memory test, delayed recall	logical memory test is a part of a neuropsychological test named Wechsler	3 month