Better Memory With Literacy Acquisition Later in Life

Memory Impairment Clinical Trial

Official title:

Better Memory With Literacy Acquisition Later in Life

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04473235
• Other study ID #: P0541386
• Status: Completed
• Phase: N/A
• Start date: November 11, 2021
• Est. completion date: December 17, 2022

Study information

• Verified date: January 2023
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims to discover whether acquiring basic-literacy in adulthood can improve episodic memory and brain structural and functional connectivity. In a collaborative project between Brazil and USA, the investigators will use a randomized controlled trial approach to leverage the level of evidence of the benefits of basic adult-education as a possible cognitive reserve builder. If successful, the study's findings will be important in shaping policies targeting increasing access to late-life education to reduce dementia risk.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 108
• Est. completion date: December 17, 2022
• Est. primary completion date: December 17, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 40 Years to 89 Years

Eligibility

Inclusion Criteria:

Being illiterate (TOFHLA score <53) and availability to participate in the study for at least 12 months

Exclusion Criteria:

A) Presence of remarkable cognitive complains and/or decompensated psychiatric illness (depression and anxiety) and/or current substance abuse such as alcohol and illicit drugs use.

B) Objective cognitive impairment: score of 2 standard deviations or bellow for age and education on the Mini-Mental State Evaluation (MMSE) and/or score of 6 or lower on the delayed recall task from the Brief Cognitive Battery.

C) History of previously diagnosed dyslexia D) Formal MRI contraindications including metal or claustrophobia. E) Severe structural lesions detected by MRI.

Related Conditions & MeSH terms

• Memory Impairment

Intervention

Behavioral:
• Literacy training
Teaching adults how to read and write using the analytical and phonemic method
• Non-Literacy training
Attending classes in geography, history, sciences, without receiving the specific training in literacy

Locations

Country	Name	City	State
Brazil	Universidade Federal de Minas Gerais	Belo Horizonte	Minas Gerais

Sponsors (2)

Lead Sponsor	Collaborator
University of California, San Francisco	Federal University of Minas Gerais

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Episodic memory improvement	Change in free recall sum-of-attempts of the Free and Cued Selective Reminding with Immediate Recall (FCSR-IR) test	6 months
Secondary	Brain connectivity improvement	Change in hippocampus-prefrontal cortex functional and structural connectivity	6 months