Memory Disorders Clinical Trial
Official title:
Attention and Memory Disorders Related to Acute Morphine
The aim of the study is to determine if there are attention disorders related to acute
morphine use in single-traumatized patients and after that the investigators will determine
whether there are immediate memory problems associated with acute morphine withdrawal in
single-traumatized patients.
From a biochemical point of view, the analgesic effects of morphine and the central side
effects appear to be two different dimensions of the action of morphine, each related to a
metabolite. Regarding acute attention, it is difficult to differentiate attention deficit
disorder due to pain or due to morphine.
Two tests have been validated in the literature to evaluate attention and memory: the 15
words of Rey and the Stroop Color Word test. The investigators will use these two tests in
this study.
Morphine is a powerful analgesic used in chronic non-neuropathic cancerous (Walsh) and
non-cancerous (Zenz et al) pain and for the relief of acute trauma pain, for example.
It is know that morphine as well as pain can cause cognitive disorders but the pain seems to
slow down the reaction time whereas morphine has an action on the long-term memory (Lorenz J
et al). According to an experimental study on rats, low dose morphine (equivalent to that
present in the human brain) does not cause long-term memory problems, as opposed to a higher
dose. In healthy volunteers, a single dose of morphine gives little cognitive and psychomotor
dysfunction (Hank et al). After 12 months of taking oral morphine, no cognitive dysfunction
is detected, with even some improvement for some functions related to stopping pain. More
recently, it has been shown that long-term morphine use causes spatial memory disturbances
and that these are probably due to extracellular adenosine accumulation.
This work suggests that acute morphine could lead to memory and attention disorders. This
would therefore result in intrinsic impairment of the cognitive abilities of the patient and
thus an alteration of his understanding in the explanations given concerning a possible
surgical intervention, the risks and benefits of it.
The purpose of the study is to assess the patient's attention and memory skills after acute
morphine use. In order to know their initial capacities, the tests are also done remotely
outside the influence of the analgesic drugs given to the emergency services. The two
practical tests, the Stroop Color Word Test and Rey's 15-word test, are easily performed
tests in an emergency context and validated in the literature.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03894254 -
Predictive Factors of Autonomy Loss in Real-life Cohort
|
N/A | |
Terminated |
NCT02521558 -
Effectiveness of Home-based Electronic Cognitive Therapy in Alzheimer's Disease
|
N/A | |
Completed |
NCT00355498 -
Amyloid Plaque and Tangle Imaging in Aging and Dementia
|
||
Completed |
NCT00010920 -
Preventing Cognitive Decline With Alternative Therapies
|
Phase 3 | |
Not yet recruiting |
NCT04079075 -
Multiple Interventions to Prevent Cognitive Decline
|
N/A | |
Completed |
NCT02185222 -
Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint
|
Phase 3 | |
Completed |
NCT00289471 -
Identifying Patients With Dementia in Primary Care
|
N/A | |
Terminated |
NCT00548327 -
The Effects of Atomoxetine on Cognition and Brain Function Based on Catechol-O-methyltransferase(COMT) Genotype
|
Phase 2 | |
Completed |
NCT00403507 -
Exercise Treatment of Mild-Stage Probable Alzheimer's Disease
|
Phase 2 | |
Completed |
NCT00387062 -
Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment
|
Phase 1 | |
Completed |
NCT04587583 -
WeCareAdvisor: A Web-Based Tool to Improve Quality of Life for Military Veterans With Dementia and Their Caregivers
|
Phase 1/Phase 2 | |
Completed |
NCT02843529 -
Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI)
|
N/A | |
Active, not recruiting |
NCT03205709 -
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment
|
N/A | |
Recruiting |
NCT05509075 -
Nutraceuticals and Functional Foods
|
||
Recruiting |
NCT05065450 -
Amygdala Memory Enhancement
|
N/A | |
Recruiting |
NCT05929144 -
Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases
|
N/A | |
Active, not recruiting |
NCT03661034 -
Study of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Function (Etude Study)
|
N/A | |
Completed |
NCT02333942 -
Dementia Signal Development Study of Nautilus NeuroWave TM for the Detection of Dementia
|
||
Completed |
NCT02236416 -
Physical Exercise for Prevention of Dementia
|
N/A | |
Completed |
NCT00567060 -
Efficacy and Safety of Piracetam Taken for 12 Months in Subjects Suffering From Mild Cognitive Impairment (MCI)
|
N/A |