Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults

Memory Deficits Clinical Trial

Official title:

Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults: An fMRI Investigation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03812744
• Other study ID #: 16-391 MR 1610
• Status: Completed
• Phase: N/A
• Start date: October 1, 2016
• Est. completion date: November 30, 2018

Study information

• Verified date: January 2019
• Source: Auburn University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study was designed to characterize the changes in the brain and body associated with whole coffee cherry extract (WCCE). WCCE is a patented extract of whole coffee fruit (coffee berries) from coffea arabica. Whole coffee cherries are a source of naturally occurring nutrients. There are no known side effects or allergens associated with WCCE other than that which would be associated with a consuming typical cup of coffee.

Previous studies suggest that increases in serum concentrations of both serum total and exosomal brain-derived neurotrophic factors (BDNF) may represent one of the mechanisms responsible for improved cognitive function after acute WCCE administration. Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and the more serious decline of dementia. It can involve problems with memory, language, thinking and judgment that are greater than normal age-related changes. Furthermore, MCI is associated with reduced circulating BDNF. Due to earlier studies reporting the ability of WCCE to stimulate increases in circulating and exosomal BDNF, it has been postulated that WCCE may also acutely improve cognitive function (as measured using behavioral tasks and fMRI). The purpose of this study is to extend and elucidate the findings of previous investigations by examining the acute neurophysiological effects of WCCE using blood-oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) employing a double-blind, randomized crossover design to investigate the acute effects of a single dose of WCCE or placebo (silica oxide) on neuronal activity in older participants.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: November 30, 2018
• Est. primary completion date: November 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Complaints of memory, verified by an informant

• 55 years of age or older

Exclusion Criteria:

• MRI contraindications

• Diagnosis of Alzheimer's Disease or suspected diagnosis at the time of visit by study personnel

• Significant cerebrovascular disease

• History of cardiovascular disease

• Current or recently prescribed medication known to interfere with peripheral and/or cerebral blood flow or vascular function

Related Conditions & MeSH terms

• Memory Deficits
• Memory Disorders

Intervention

Drug:
• Whole coffee cherry extract (WCCE)
100mg WCCE
• Placebo Oral Capsule [CEBOCAP]
Silica Oxide

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Auburn University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Behavioral Measures - Change in Go/No-Go Reaction Time	Response/reaction time for each stimuli will be recorded in ms using E-Prime. Reaction times will be calculated for correct and incorrect trials separately.	Collected pre-drug, post-drug, pre-placebo, and post-placebo; through study completion (4 time points over a 72 hour period)
Primary	Behavioral Measures - Change in N-back Reaction Time	Response/reaction time for each stimuli will be recorded in ms using E-Prime. Reaction times will be calculated for correct and incorrect trials separately.	Collected pre-drug, post-drug, pre-placebo, and post-placebo; through study completion (4 time points over a 72 hour period)
Primary	Behavioral Measures - Change in Go/No-Go Accuracy	Accuracy will be determined as the number of trials correct, and errors will be classified as errors of omission or commission.	Collected pre-drug, post-drug, pre-placebo, and post-placebo; through study completion (4 time points over a 72 hour period)
Primary	Behavioral Measures - Change in N-back Accuracy	Accuracy will be determined as the number of trials correct.	Collected pre-drug, post-drug, pre-placebo, and post-placebo; through study completion (4 time points over a 72 hour period)
Primary	Change in Concentration of Neurometabolites	Magnetic resonance spectroscopy (MRS) measurements pre/post ingestion. The following are measured: glutamate, glutamine, gamma-aminobutyric acid, N-acetylaspartate, choline, creatine, glutathione, myo-inositol, aspartate, taurine, and lactate. LCModel software performed automatic quantification of in vivo proton MR spectra by analyzing spectra as a linear combination of model spectra from sequence-specific simulations. Water-suppressed spectra were eddy current corrected and quantified using the unsuppressed water signal. Cramer-Rao lower bounds were used as a measure of fit with CRLB > 50% rejected from further analysis. Metabolite concentrations were CSF-corrected, and quantified (in ppm).	Collected pre-drug, post-drug, pre-placebo, and post-placebo; through study completion (4 time points over a 72 hour period)
Primary	Change in Blood Levels of Brain Derived Neurotrophic Factor (BDNF)	Serum and exosomal BDNF concentrations	Collected pre-drug, post-drug, pre-placebo, and post-placebo; through study completion (4 time points over a 72 hour period)
Primary	Blood Oxygen Level Dependent (BOLD) Changes	Functional magnetic resonance imaging blood-oxygen-level-dependent signal changes across tasks, and during resting state	Collected pre-drug, post-drug, pre-placebo, and post-placebo; through study completion (4 time points over a 72 hour period)