Melasma Clinical Trial
Official title:
Evaluation of the Therapeutic Effect of Platelet Rich Plasma in Melasma
Verified date | June 2018 |
Source | Assiut University |
Contact | Eman R Hofny, PHD |
Phone | 01005298992 |
e_riad[@]yahoo.com | |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The therapy for melasma has always been challenging and discouraging. Platelet rich plasma has been used over the last several years as an effective treatment in various surgical and medical fields. In recent years, Platelet rich plasma has also started to be used in the field of cosmetology. This study is designed to evaluate the therapeutic effect of platelet rich plasma in melasma.
Status | Recruiting |
Enrollment | 26 |
Est. completion date | December 7, 2019 |
Est. primary completion date | December 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - patients with melasma 18 years old or more Exclusion Criteria: - Patients less than 18 years. - Pregnant females and females on oral contraceptive pills. - Patients with a history of hypertrophic scars or keloids. - Patients with recurrent herpes infection or with present cutaneous infection and those with facial cancer. - Patients with blood disorders and platelet abnormalities and chronic liver disease. - Patients using systemic chemotherapy, anticoagulation therapy and antiplatelet agents. |
Country | Name | City | State |
---|---|---|---|
Egypt | Assiut university hospitals | Assiut |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Egypt,
Cayirli M, Caliskan E, Açikgöz G, Erbil AH, Ertürk G. Regression of melasma with platelet-rich plasma treatment. Ann Dermatol. 2014 Jun;26(3):401-2. doi: 10.5021/ad.2014.26.3.401. Epub 2014 Jun 12. — View Citation
Grimes PE. Melasma. Etiologic and therapeutic considerations. Arch Dermatol. 1995 Dec;131(12):1453-7. Review. — View Citation
Kim DS, Park SH, Park KC. Transforming growth factor-beta1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation. Int J Biochem Cell Biol. 2004 Aug;36(8):1482-91. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | clinical improvement of melasma | evaluation of the degree of clinical improvement of melasma by using platelet rich plasma | 3 months | |
Secondary | evaluation of transforming growth factor beta expression in the melasma skin | compare the intensity of immunohistochemical expression of transforming growth factor beta in skin biopsies taken from the the lesional melasma skin ( of participants who accept only) before and after treatment with platelet rich plasma The results will be scored as follows: 0 for negative staining, 1+ for weak staining, 2+ for moderate staining intensity, and 3+ for strong positive staining. | 3 months |
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