Melasma Clinical Trial
Official title:
Evaluation of the Therapeutic Effect of Platelet Rich Plasma in Melasma
Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The therapy for melasma has always been challenging and discouraging. Platelet rich plasma has been used over the last several years as an effective treatment in various surgical and medical fields. In recent years, Platelet rich plasma has also started to be used in the field of cosmetology. This study is designed to evaluate the therapeutic effect of platelet rich plasma in melasma.
Melasma is a pigmentary disorder that can be disfiguring and can cause to significant
emotional stresses for sufferers, for which a universally effective treatment is still
lacking. Platelet rich plasma is commonly used in dermatology and plastic surgery, especially
for treating chronic wounds, ulcers, and burns. The most important contents of platelets are
contained in the α-granules. Some of the bioactive substances present in the α-granules
include platelet-derived growth factor, transforming growth factor -β1 and -β2epidermal
growth factor, and mitogenic growth factors such as platelet-derived angiogenesis factor and
fibrinogen.
transforming growth factor -β1 decreases melanogenesis via delayed extracellular
signal-regulated kinase activation. The regression of melasma in a 27-years-old woman after
injecting platelet rich plasma for skin rejuvenation was observed, but controlled clinical
trials are still lacking to confirm this preliminary observation.
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