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Clinical Trial Summary

Melasma is an acquired disorder of pigmentation that leads to irregular pigmented patches on the face. Treatment is difficult and to date the best treatment option is the combination of hydroquinone, retinoic acid and steroids combined in topical daily application (called Kligman's trio). Q-switched pigmentary lasers are usually ineffective and can induce post inflammatory hyperpigmentation (PIH). Intense pulsed light can sometimes improve melasma but also induce PIH which limit their use. Recently, pulsed dye laser were demonstrated to be effective in treating some pigmentary defects. Associating blanching cream with hydroquinone to prevent PIH after laser or intense pulsed light has been already reported with success.

The objective of the study is to compare in a prospective intra individual comparative trial the association of pulsed dye laser plus stabilized Kligman's trio to Kligman's trio alone. The secondary objective was to study the frequency and the intensity of the potential side effects including PIH.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00863278
Study type Interventional
Source Centre Hospitalier Universitaire de Nice
Contact
Status Terminated
Phase Phase 4
Start date March 2009
Completion date December 2010

See also
  Status Clinical Trial Phase
Completed NCT01976273 - A Pilot Study Testing 1064nm Q-switch Laser Versus Glycolic Acid Peels for the Treatment of Melasma N/A
Completed NCT05119413 - Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of Melasma Phase 2
Recruiting NCT00927771 - Azelaic Acid Versus Hydroquinone in Melasma Phase 4
Not yet recruiting NCT05930366 - Comparative Evaluation of Microsurgery vs Diode Laser Technique of Gingival Depigmentation N/A
Not yet recruiting NCT05930392 - Comparative Evaluation of Microsurgery vs Conventional Surgical Technique of Gingival Depigmentation N/A
Active, not recruiting NCT01976286 - A Pilot Study Testing Salicylic Acid Peels Versus Glycolic Acid Peels for the Treatment of Melasma N/A
Not yet recruiting NCT03585179 - Oral and Topical Tranexamic Acid for the Treatment of Melasma Phase 3