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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05607095
Other study ID # 22-109
Secondary ID
Status Recruiting
Phase Phase 1
First received
Last updated
Start date November 1, 2022
Est. completion date May 1, 2025

Study information

Verified date May 2024
Source Memorial Sloan Kettering Cancer Center
Contact Alexander Shoushtari, MD
Phone 646-888-4161
Email shoushta@mskcc.org
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This is an open label study evaluating lifileucel (LN-144) in patients with metastatic uveal melanoma.


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Study Design


Intervention

Biological:
Lifileucel (LN-144)
Lifileucel (LN-144) is an autologous Tumor Infiltrating Lymphocytes (TIL) cell therapy that utilizes a 22-day centralized GMP process. Lifileucel is infused as part of a treatment regimen that includes preparative NMA-LD, followed by one-time autologous TIL infusion, and a short course of high-dose IL-2.

Locations

Country Name City State
United States Memorial Sloan Kettering Westchester Harrison New York
United States Memorial Sloan Kettering Cancer Center (All Protocol Activities) New York New York

Sponsors (2)

Lead Sponsor Collaborator
Memorial Sloan Kettering Cancer Center Iovance Biotherapeutics, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Adverse events as evaluated by CTCAE v5.0 Safety will be measured descriptively using CTCAE v5.0 for all patients who undergo surgical excision. Up to 3 years
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