Neoadjuvant Nivolumab+Ipilimumab Followed by Adjuvant Nivolumab or

Status Withdrawn

Clinical Trial Summary

The purpose of this study is to evaluate the role of neoadjuvant immunotherapy and to demonstrate high pathologic complete response (pCR) and near pCR rates in melanoma participants with clinically detectable nodal disease and a high risk of recurrence. Neoadjuvant immunotherapy aims to enhance the systemic T-cell response to tumor antigens while detectable tumor is still present, inducing a stronger and broader tumor-specific immune response. Of the neoadjuvant approaches studied within melanoma, the neoadjuvant combination of nivolumab and ipilimumab has demonstrated high pCR and near pCR rates that may translate to prolonged clinical benefit.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Melanoma

Clinical Trial Details

NCT number	NCT04495010
Study type	Interventional
Source	Bristol-Myers Squibb
Contact
Status	Withdrawn
Phase	Phase 2
Start date	March 31, 2021
Completion date	October 23, 2027

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See also
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Neoadjuvant Nivolumab+Ipilimumab Followed by Adjuvant Nivolumab or Neoadjuvant Nivolumab+Ipilimumab Followed by Adjuvant Observation Compared With Adjuvant Nivolumab in Treatment-Naive High-risk Melanoma Participants — CheckMate 7UA

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms