Melanoma Clinical Trial
Official title:
Expansion ex Vivo Des Cellules Tumorales Circulantes Comme modèle de Pharmacologie prédictive Des Cancers. EXPEVIVO-CTC
Several studies conducted over the past decade have shown that Circulating tumor cells (CTCs)
can be used as a marker for predicting disease progression and survival in patients with
early or metastatic cancer. A high number of CTCs correlate with aggressive disease,
increased metastasis and decreased survival rates.
Knowledge of metastasis mechanisms was mainly obtained from mouse models with CTCs after
orthotopic transplants. The only possibility to study the patient's CTC subpopulations is to
carry out ex-vivo expansion and develop an animal model with CTC xenograft. Because
circulating blood collection is simple and non-invasive, CTCs can be used as a marker to
track disease progression and survival in real time. CTCs could also guide therapeutic
choice.
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